A 93-year-old woman was pulled to safety after emergency services attended the scene at about 00:40 BST this morning.
She has been taken to North Manchester general hospital and is said to be in a serious condition. It is understood that she is the elderly man's wife.
A Greater Manchester police spokeswoman said that inquiries are continuing into the cause of the fire.
Click here to run an energy price comparison, and see if you could be paying less for your gas and electricity.